Are NSAIDs Really Safe For Me?

(NSAID’s) in non steroidal anti-inflammatory drugs is inhibit the action of prostaglandins see below

When foreign particals enter into the body or tissue damage occurs their release enzyme phospholipase (A2) which breaks down the fat layers of cell membrane.

From this breakdown a substance arachidonic acid is produce. Arachidonic acid combine with enzyme cyclo-oxygenase( COX) converted into prostaglandins which play role in pain and  Inflammation .

NSAID’s reduce the level of prostaglandins by inhibiting the enzyme cyclo-oxygenase further prostaglandin are not produce.

Indications Of NSAID’s
NSAID’s is recommended in

Acute /Chronic pain
Low back pain
Rheumatoid arthritis
Juvenile arthritis
Primary dysmenorrhea
Post operative pain
Muscle injuries
Ankylosing spondylitis
All types of pain NSAID’s is recommended
NSAID’s Brand.
Mefenamic acid
What is Skeleton ?
The skeleton is a framework for the body made of bones. Because other tissues are closely associated with the skeleton, the term skeletal system is more useful. The skeletal system consists of bones, cartilage and joints.

Functions of the Skeletal System

Support for body and its parts
Protection of soft-tissues and organs
Reservoir for calcium
Movement (with muscular system)
What is Rheumatic Disorders ?
Rheumatism is a general term that covers a wide range of disorders affecting the musculo-skeletal system, especially synovial joints and soft tissue around them. Musculo-skeletal disorders and rheumatic diseases or disorders are other term that broadly cover the same field.

Examples of rheumatic disorders are osteoarthritis, rheumatoid arthritis, tendonitis and sprains.

What is Osteoarthritis ?
Osteoarthritis, or osteoarthrosis, is a chronic condition in which one or more synovial joints deteriorate with potential loss of function. It is the commonest joint disease.

Osteoarthritis can affect various joints but not in a symmetrical way, unlike rheumatoid arthritis. Clinical features vary. Joints commonly affected are those of the hands and feet, knees, hips, and spine.

Symptoms in Osteoarthritis:

Loss of function (restriction of movement)
What is Rheumatoid Arthritis ?
Rheumatoid arthritis is a chronic, inflammatory and destructive disease of synovial joints. It can also produce potentially serious systemic effects. The disease affects mainly peripheral joints, such as the hands and feet, in a symmetrical way.

What is Ankylosing Spondylitis ?
Ankylosing spondylitis, or Bechterews Disease, is a chronic inflammatory disease that mainly affects the joints between the vertebrae of the spine. The joints stiffen and movement becomes restricted. In severe cases, the joints fuse (ankylosis) and the spine becomes rigid. This “bamboo spine” can be seen on X-ray other joints and organs can become involved.

What is Tendinitis ?
Tendinitis is also known as tendinopathy. Tendinitis is the inflammation of tendon that results in pain, swelling, and impaired function. The pain is typically worse with movement.

Tendinitis most commonly occurs around the shoulder (rotator cuff tendinitis, biceps tendinitis), elbow (tennis elbow, golfer’s elbow), wrist, hip, knee (jumper’s knee), or ankle (Achilles tendinitis).

Common Side Effects Of NSAID’s:
Stomach pain and heartburn.
Stomach ulcers.
Headaches and dizziness.
Ringing in the ears.
Allergic reactions such as rashes, wheezing.
Liver or kidney problems. …
High blood pressure.


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